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Updated: Jun 12, 2026

Amide Coupling Reaction for the Synthesis of Bispyridine-based Ligands and Their Complexation to Platinum as Dinuclear Anticancer Agents
Published on: May 28, 2014
Synthesis and structural characterization of a fused bispyrone and preparation of the first metal bispyrylium
Kristopher V Waynant1, James D White, Lev Zakharov
1Department of Chemistry, Oregon State University, Corvallis, OR, USA.
Abstract:
Dehydroacetic acid reacts with acetic anhydride in the presence of perchloric acid to give a salt which upon careful neutralization affords a fused bis-gamma-pyrone. The bis-gamma-pyrone forms stable metal complexes with Li, Mg, Cu(II), Ni(II), Zn, Fe(II), Co(II) and Ba perchlorates whose crystal structures reveal that the ligand possesses significant bispyrylium character while the metal is coordinated at the negatively charged edge of the structure.
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