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Updated: Jun 12, 2026

Vascular Balloon Injury and Intraluminal Administration in Rat Carotid Artery
Published on: December 23, 2014
[Endothelin antagonists and their role in pharmacotherapy]
1Uniwersytet Jagielloński, Collegium Medicum, Katedra Patofizjologii. lukaszd@mp.pl
Abstract:
Endotelina (ET-1) is the polypeptide about wide spectrum of physiological effects, involved in pathophysiology of cardiovascular and neoplastic diseases. Thus, ET-1 blocking becomes modern therapeutic target. The endothelin receptor antagonists (ERA)--sentans are the intensely studied agents, already approved for an alternative pulmonary hypertension therapy and hormone-resistant prostate cancer treatment. The promising results of conducted clinical trials suggest the possible extension of ERA application in other clinical entities in the close future. The article shortly describes present studied endothelin receptor antagonists and rationale for their introduction to the general clinical practice.
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