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Bilateral and recurrent optic neuritis in multiple sclerosis.

J Burman1, R Raininko, J Fagius

  • 1Department of Neuroscience/Neurology, Uppsala University, Sweden. joachim.burman@akademiska.se

Acta Neurologica Scandinavica
|June 24, 2010
PubMed
Summary
This summary is machine-generated.

Recurrent optic neuritis (ON) is a common initial symptom in multiple sclerosis (MS). This study highlights the frequency of ON in MS patients, differentiating it from neuromyelitis optica (NMO).

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Area of Science:

  • Neuroimmunology
  • Neurology
  • Ophthalmology

Background:

  • Optic neuritis (ON) is a significant neurological condition.
  • Understanding the patterns of ON in multiple sclerosis (MS) is crucial for diagnosis and management.
  • Distinguishing MS-related ON from other conditions like neuromyelitis optica (NMO) is clinically important.

Purpose of the Study:

  • To determine the incidence of bilateral and recurrent optic neuritis (ON) in multiple sclerosis (MS) patients.
  • To compare the epidemiological data of ON in MS with neuromyelitis optica (NMO) and isolated recurrent ON.

Main Methods:

  • Analysis of 472 patients diagnosed with MS from the Swedish Multiple Sclerosis Register.
  • Evaluation of patients for the presence of ON, its presentation as the initial symptom, laterality (unilateral/bilateral), and recurrence.

Main Results:

  • Twenty-one percent of MS patients presented with ON as their first symptom.
  • 5.5% of patients experienced a second ON attack before other MS manifestations appeared.
  • Recurrent bilateral ON as the presenting symptom occurred in 3.8% of cases; simultaneous bilateral ON was rare (0.42%).

Conclusions:

  • Recurrent ON, both unilateral and bilateral, is a frequent presenting feature of MS.
  • Given MS's higher prevalence than NMO, careful diagnostic work-up is essential for recurrent ON.
  • Repeated MRI and lumbar punctures may be necessary for accurate diagnosis, even with positive NMO-IgG markers.