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Updated: Jun 12, 2026

A Magnetic Resonance Imaging-based Computational Protocol for Analysis of Plaque Morphology and Hemodynamics in Patients with Carotid Artery Stenosis
09:36

A Magnetic Resonance Imaging-based Computational Protocol for Analysis of Plaque Morphology and Hemodynamics in Patients with Carotid Artery Stenosis

Published on: August 12, 2025

Acute increase of complexity in the neurocardiovascular dynamics following carotid stenting

H-K Yuan1, C Lin, P-H Tsai

  • 1Department of Biomedical Engineering, Duke University, Durham, NC, USA.

Acta Neurologica Scandinavica
|June 24, 2010
PubMed

Insights

Carotid angioplasty and stenting (CAS) improves autonomic regulatory dynamics in patients with high-grade carotid stenosis. This study found increased heart rate variability complexity after CAS, suggesting a healthier neurocardiovascular state.

Area of Science:

  • Cardiovascular Physiology
  • Autonomic Nervous System Regulation
  • Interventional Cardiology

Background:

  • Percutaneous carotid angioplasty and stenting (CAS) aims to enhance cerebral blood flow.
  • The impact of CAS on autonomic regulatory dynamics is not well understood.
  • Neurocardiovascular dynamics play a crucial role in maintaining homeostasis.

Purpose of the Study:

  • To investigate the effects of primary CAS on neurocardiovascular regulatory dynamics.
  • To assess changes in heart rate variability (HRV) and multiscale entropy (MSE) post-CAS.
  • To determine if CAS influences the complexity of heart beat interval regulation.

Main Methods:

  • Prospective study involving 12 male patients undergoing unilateral primary CAS.
  • Electrocardiograms recorded pre-operatively, 1-hour post-operatively, and 1-day post-operatively.
  • Analysis using conventional HRV and multiscale entropy (MSE) to quantify autonomic activity and regulatory complexity.

Main Results:

  • Conventional HRV indices showed no significant changes post-CAS.
  • Multiscale entropy (MSE) complexity significantly increased on scales 2-8 at 1-hour and scales 2-3 at 1-day post-treatment.
  • Increased complexity suggests a potential restoration of neurocardiovascular dynamics.

Conclusions:

  • Primary CAS can lead to recovery in neurocardiovascular regulatory dynamics.
  • The findings indicate a positive impact of CAS on autonomic regulation in patients with high-grade carotid stenosis.
Abstract

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