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Published on: October 11, 2019
[Expression and significance of Fas/APO-1 and Bcl-2 protein in human lung cancer.]
1Department of Thoracocardiac Surgery , 175th Hospital of People's Liberation Army , Zhangzhou , Fujian 363000 , P. R. China.
Background:
To investigate the role of Fas/APO-1 and Bcl-2 in oncogenesis and progression of lung cancer.
Methods:
The expression of Fas/APO-1 and Bcl-2 protein were detected in 65 lung cancer tissues and 46 normal lung tissues by immunohistochemistry.
Results:
The positive rate of Fas/APO-1 protein expression in lung cancer tissues was 56. 92 % , which was significantly lower than that in normal lung tissues (82. 61 %) ( P < 0. 01) . The positive rate of Bcl-2 protein expression was 46. 15 %. It was significantly higher than that in normal lung tissues (6. 52 %) ( P < 0. 01) .
Conclusions:
Both Fas/APO-1 and Bcl-2 may play an role in the oncogenesis and progression of lung cancer.
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