[Neurofibromatosis type 1--own experiences].

Area of Science:

• Ophthalmology
• Genetics
• Neurology

Context:

• Neurofibromatosis type 1 (NF1) is a common inherited disorder.
• Ocular manifestations are frequently associated with NF1.
• Understanding age-related symptom progression is crucial for patient management.

Purpose:

• To evaluate the prevalence and characteristics of eye symptoms in patients with NF1.
• To determine how eye symptom frequency varies across different age groups.

Summary:

• This study observed 52 NF1 patients (ages 3-49) divided into five age groups.
• Ophthalmological signs were present in 69.2% of patients, with higher frequency in older groups.
• After age 21, all patients showed signs, including café-au-lait spots, Lisch nodules, CNS changes, and orbital neurofibromas.

Impact:

• Highlights the high prevalence of ocular symptoms in NF1.
• Demonstrates a clear age-dependent increase in eye symptom manifestation.
• Provides age-specific insights into common NF1 ocular findings for clinicians.