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Culture and Imaging of Ex Vivo Organotypic Pseudomyxoma Peritonei Tumor Slices from Resected Human Tumor Specimens
Published on: December 9, 2022
Mesenteric cyst: report of a case-resulting in pseudomyxoma peritonei
Luis Zappa1, Paul H Sugarbaker
1Washington Cancer Institute, 106 Irving St, NW, Suite 3900, Washington, DC 20010, USA.
Background:
A mesenteric cyst may have an embryonic, traumatic, neoplastic or infectious origin. In rare cases mesenteric cysts may contain neoplastic epithelium. A mesenteric cyst has not previously been recorded as the cause of pseudomyxoma peritonei.
Methods:
A patient who developed widespread mucinous intraperitoneal tumor as a result of a ruptured mesenteric cyst is reported. A literature review of the clinical features, diagnosis, treatment, and prognosis of the mesenteric cyst is presented.
Results:
This patient was treated with cytoreductive surgery and perioperative intraperitoneal chemotherapy. Her recovery was uneventful and she remains well two years after treatment.
Conclusion:
Mesenteric cyst is a rare cause of pseudomyxoma peritonei. The definite treatment of a ruptured neoplastic mesenteric cyst can, by analogy, be compared to the treatment for pseudomyxoma peritonei of appendiceal origin. The results of cytoreductive surgery with perioperative intraperitoneal chemotherapy are expected to be good.
Insights
A ruptured mesenteric cyst, a rare cause of pseudomyxoma peritonei, was successfully treated with cytoreductive surgery and intraperitoneal chemotherapy. This approach offers a promising treatment for similar neoplastic mesenteric cyst cases.
Area of Science:
- Gastroenterology
- Surgical Oncology
Background:
- Mesenteric cysts, with diverse origins (embryonic, traumatic, neoplastic, infectious), can rarely harbor neoplastic epithelium.
- Mesenteric cysts have not been previously documented as a cause of pseudomyxoma peritonei.
Observation:
- A case report details a patient who developed widespread mucinous intraperitoneal tumor following a ruptured mesenteric cyst.
- The patient underwent cytoreductive surgery and perioperative intraperitoneal chemotherapy for the condition.
- Recovery was uneventful, with the patient remaining well two years post-treatment.
Findings:
- Mesenteric cyst is identified as a rare etiology for pseudomyxoma peritonei.
- The study suggests that treatment for ruptured neoplastic mesenteric cysts can be extrapolated from protocols for appendiceal pseudomyxoma peritonei.
- Successful management involved cytoreductive surgery and perioperative intraperitoneal chemotherapy.
Implications:
- This case highlights the importance of considering mesenteric cysts in the differential diagnosis of pseudomyxoma peritonei.
- The findings support the efficacy of cytoreductive surgery and intraperitoneal chemotherapy for managing pseudomyxoma peritonei originating from mesenteric cysts.
- Further research into the neoplastic potential of mesenteric cysts and their management is warranted.
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