Related Experiment Video
Updated: Jun 12, 2026
07:39
Use of a Percutaneous Ventricular Assist Device/Left Atrium to Femoral Artery Bypass System for Cardiogenic Shock
Published on: August 16, 2021
Non-pulsatile circulation with axial-flow left ventricular assist device preserves neurocognitive function
Helena Argiriadou1, Kalliopi Megari, Polychronis Antonitsis
1Department of Anesthesia and Intensive Care, Aristotle University of Thessaloniki, AHEPA Hospital, Thessaloniki, Greece.
Perfusion
|June 25, 2010
Summary
New axial-flow pumps may affect brain function. This study found no neurocognitive decline in a patient with a Jarvik 2000 left ventricular assist device over six months.
Area of Science:
- Cardiology
- Neurology
- Medical Devices
Background:
- Newer axial-flow left ventricular assist devices (LVADs) create non-pulsatile blood flow.
- Concerns exist regarding the impact of non-pulsatile flow on neurocognitive function.
Observation:
- A patient implanted with a Jarvik 2000 continuous-flow LVAD was evaluated.
- Neurocognitive function was assessed preoperatively and at 1 and 6 months post-implantation.
Findings:
- A comprehensive neuropsychological test battery was utilized.
- A slight improvement was observed in specific neurocognitive domains.
- No neurocognitive decline was evident at the 6-month follow-up.
Implications:
- The Jarvik 2000 LVAD may not negatively impact neurocognitive function.
- Further research is warranted to confirm these findings in a larger patient cohort.
- This study contributes to understanding the neurological safety of continuous-flow LVADs.
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