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Updated: Jun 12, 2026

In Vivo Quantitative Assessment of Myocardial Structure, Function, Perfusion and Viability Using Cardiac Micro-computed Tomography
Published on: February 16, 2016
The role of noninvasive imaging in promoting cardiovascular health
Valentin Fuster1, Torsten P Vahl
1Centro Nacional de Investigaciones Cardiovasculares (CNIC), Madrid, Spain. valentin.fuster@mssm.edu
Insights
Cardiovascular disease (CVD) is a global health crisis. Novel imaging can detect subclinical atherosclerosis early, enabling better risk factor management and potentially preventing serious cardiovascular events.
Area of Science:
- Cardiology
- Medical Imaging
- Preventive Medicine
Background:
- Cardiovascular disease (CVD) is the leading global cause of mortality, imposing a significant economic burden.
- Current CVD prevention focuses on established risk factors like hypertension and hypercholesterolemia.
- Atherosclerosis is often diagnosed late, after symptomatic events like heart attack or stroke.
Purpose of the Study:
- To highlight the potential of novel noninvasive imaging techniques.
- To emphasize the importance of early detection of subclinical atherosclerosis.
- To improve the management of cardiovascular risk factors in affected individuals.
Main Methods:
- Review of studies on novel noninvasive imaging techniques.
- Analysis of the role of imaging in identifying subclinical atherosclerosis and high-risk plaques.
- Evaluation of the impact of early detection on clinical practice.
Main Results:
- Novel noninvasive imaging shows promise in identifying subclinical atherosclerosis.
- Early detection of high-risk plaques is feasible with current technologies.
- Identifying subclinical disease allows for earlier intervention and risk factor control.
Conclusions:
- Early detection of subclinical atherosclerosis is crucial for effective CVD prevention.
- Noninvasive imaging can facilitate timely intervention, potentially reducing CVD morbidity and mortality.
- Improved risk factor management following early diagnosis can mitigate the impact of atherosclerosis.
Abstract:
Cardiovascular disease (CVD) is the leading cause of death worldwide, and its prevalence is likely to increase in the near future. The morbidity and mortality associated with CVD causes an enormous economic burden, which has become a major problem for many societies across the globe. The current prevention strategies are aimed at identifying and reducing established risk factors for atherosclerosis including hypertension, hypercholesterolemia, diabetes, obesity, smoking, and sedentary lifestyle. However, some of our prevention goals, such as reducing LDL cholesterol, change dramatically once a subject has been diagnosed with coronary atherosclerosis. At the present time, atherosclerosis is frequently diagnosed relatively late in the course of the disease, when a patient develops symptoms or presents with acute events such as an acute coronary syndrome or a stroke. Several studies have demonstrated that novel noninvasive imaging techniques have the potential to identify subclinical atherosclerosis and high-risk plaques. Early detection of subclinical atherosclerosis may enable clinicians to improve the control of cardiovascular risk factors in affected patients earlier, thereby helping to prevent some of the manifestations of CVD.
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