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Unusual eta2-allene osmacycle with apoptotic properties

Xumin He1, Lei Gong, Katja Kräling

  • 1State Key Laboratory of Physical Chemistry of Solid Surfaces, College of Chemistry and Chemical Engineering, Xiamen University, Xiamen, 361005, China.

Chembiochem : a European Journal of Chemical Biology
|June 25, 2010
PubMed
Summary

A novel osmium-allene complex exhibits potent anti-cancer activity by inducing apoptosis in lymphoma cells. This metallacycle targets mitochondria, initiating programmed cell death through oxidative decomposition.

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