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Biosynthesis of a Flavonol from a Flavanone by Establishing a One-pot Bienzymatic Cascade
Published on: August 14, 2019
[Microbiological transformation of paeoniflorin and albiflorin]
Xinxin Liu1, Xiaochi Ma, Changhong Huo
1School of Pharmacy, Hebei Medical University, Shijiazhuang 050017, China.
Objective:
To investigate the microbiological transformation of paeoniflorin and albiflorin.
Method:
The bacteria strains able to transform paeoniflorin and albiflorin were screened from 18 strains of microorganisms. The products were isolated by chromatography method and their structures were elucidated by spectral technology.
Result:
It was found that Cunninghamella blakesleana (AS 3.970) and Syncephalastrum racemosum (AS 3.264) could convert paeoniflorin and albiflorin efficiently, respectively. C. blakesleana could convert paeoniflorin to produce albiflorin, while S. racemosum could convert albiflorin to produce paeoniflorin.
Conclusion:
Paeoniflorin and albiflorin could be converted each other in definited condition.
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