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Labdanes and sucrose esters from Physalis sordida.
Ana-L Pérez-Castorena1, Mahinda Martínez, Emma Maldonado
1Instituto de Quimica, Universidad Nacional Autonoma de Mexico, Circuito Exterior, Ciudad Universitaria, Coyoacan 04510, D.F., Mexico. alperezc@servidor.unam.mx
Journal of Natural Products
|June 26, 2010
Summary
New compounds from Physalis sordida, including sucrose esters 12 and 15, exhibit potent anti-inflammatory effects. These natural products show activity comparable to indomethacin in a mouse ear edema model.
Area of Science:
- Natural Product Chemistry
- Pharmacology
Background:
- Physalis sordida is a plant species with potential medicinal properties.
- Isolation and characterization of novel compounds from natural sources are crucial for drug discovery.
Purpose of the Study:
- To isolate and characterize new chemical constituents from the aerial parts of Physalis sordida.
- To evaluate the anti-inflammatory potential of isolated compounds.
Main Methods:
- Spectroscopic techniques (NMR, MS) and chemical transformations were used for structure elucidation.
- X-ray crystallographic analysis confirmed the structure of compound 10.
- Anti-inflammatory activity was assessed using the TPA-induced mouse ear edema test in mice.
Main Results:
- Eight new compounds were identified: three labdanes (2-4), one homoergostane (10), and four sucrose esters (12-15).
- Compounds 12 and 15 demonstrated significant anti-inflammatory activity, with IC(50) values of 0.26 and 0.24 mumol/ear, respectively.
- This activity was comparable to the positive control, indomethacin (IC(50) 0.24 mumol/ear).
Conclusions:
- Physalis sordida is a source of novel labdanes, homoergostanes, and sucrose esters.
- Sucrose esters 12 and 15 possess notable anti-inflammatory properties.
- These findings suggest potential therapeutic applications for Physalis sordida-derived compounds in managing inflammation.
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