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Low serological positivity in patients with histology compatible with celiac disease in Perú
F Arévalo1, E Roe, J Arias-Stella-Castillo
1Servicio de Anatomía Patológica, Hospital Daniel Alcides Carrión, Lima, Perú. fer13013@hotmail.com
Objective:
To study the frequency of positive serology for celiac disease (CD) in patients with duodenal biopsies suggestive of this disease.
Material And Methods:
Cross sectional study. We included patients with duodenal biopsies histologically compatible with CD and antigliadin, antiendomysial and IgA antitransglutaminase antibodies. We defined a "case" of CD if there was a positive biopsy and either antiendomisial or antitransglutaminase positive antibodies.
Results:
Thirty one patients were included in our study. Six were antiendomysial positive and 5 antitransglutaminase positive while the antigliadin was positive in 14 cases. Therefore, out of 31 patients only 10 had a serology compatible with CD and only one had positive both antibodies, antiendomysial and antitransglutaminase.
Conclusions:
a) We have found that most of the duodenal biopsies compatible with CD are not diagnosed with positive serology; and b) we found a low correlation between serological diagnostic tests.
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