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Related Concept Videos

Diabetic Retinopathy01:27

Diabetic Retinopathy

DefinitionDiabetic retinopathy is a microvascular complication of diabetes affecting the retinal blood vessels.Risk FactorsDiabetic retinopathy is present in almost all individuals with type 1 diabetes and more than 60% of those with type 2 diabetes after two decades of disease.The risk increases with poor glycemic control, hypertension, dyslipidemia, smoking, pregnancy, and puberty.Although cataracts and glaucoma are also more frequent in people with diabetes, retinopathy remains the leading...
The Retinoblastoma Gene01:20

The Retinoblastoma Gene

Tumor suppressor genes are normal genes that can slow down cell division, repair DNA mistakes, or program the cells for apoptosis in case of irreparable damage. Hence, they play an essential role in preventing the proliferation of damaged cells.
The first-ever tumor suppressor gene called Rb was identified in retinoblastoma - a rare eye tumor in children. In inherited forms of the disease, a child inherits one defective copy of the Rb gene, which predisposes them to retinoblastoma. However,...
The Retinoblastoma Gene01:20

The Retinoblastoma Gene

Tumor suppressor genes are normal genes that can slow down cell division, repair DNA mistakes, or program the cells for apoptosis in case of irreparable damage. Hence, they play an essential role in preventing the proliferation of damaged cells.
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Photoreceptors and Visual Pathways01:22

Photoreceptors and Visual Pathways

At the molecular level, visual signals trigger transformations in photopigment molecules, resulting in changes in the photoreceptor cell's membrane potential. The photon's energy level is denoted by its wavelength, with each specific wavelength of visible light associated with a distinct color. The spectral range of visible light, classified as electromagnetic radiation, spans from 380 to 720 nm. Electromagnetic radiation wavelengths exceeding 720 nm fall under the infrared category, whereas...
Glaucoma: Overview01:25

Glaucoma: Overview

Glaucoma is an eye condition characterized by increased intraocular pressure that damages the retina and optic nerve, leading to irreversible blindness if left untreated. The human eye has various components, including the cornea, iris, pupil, lens, and optic nerve. Aqueous humor is secreted by the epithelium of the ciliary body in the posterior chamber and flows through the trabecular meshwork and canal of Schlemm, maintaining normal intraocular pressure. The trabecular meshwork and the canal...
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Open Angle Glaucoma: Treatment

In open-angle glaucoma, the iridocorneal angle remains open, but the trabecular meshwork becomes stiff, slowing down the outflow of aqueous humor. This causes a buildup of aqueous humor in the anterior chamber, leading to a sudden increase in intraocular pressure. The treatment for open-angle glaucoma focuses on reducing the elevated intraocular pressure by either decreasing the secretion of aqueous humor or increasing its outflow.
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Related Experiment Video

Updated: Jun 12, 2026

Ex Vivo OCT-Based Multimodal Imaging of Human Donor Eyes for Research into Age-Related Macular Degeneration
10:14

Ex Vivo OCT-Based Multimodal Imaging of Human Donor Eyes for Research into Age-Related Macular Degeneration

Published on: May 26, 2023

[Familial exudative vitreoretinopathy].

D Finis1, J Stammen, A M Joussen

  • 1Augenklinik, Heinrich-Heine-Universität Düsseldorf, Düsseldorf, Germany.

Der Ophthalmologe : Zeitschrift Der Deutschen Ophthalmologischen Gesellschaft
|June 26, 2010
PubMed
Summary
This summary is machine-generated.

Familial exudative vitreoretinopathy (FEVR) is a genetic eye disorder primarily affecting Asians, causing vision loss through retinal detachment. Early therapy, including vessel coagulation or vitrectomy, is crucial for preserving sight in affected individuals.

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Last Updated: Jun 12, 2026

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Area of Science:

  • Ophthalmology
  • Genetics
  • Retinal Diseases

Context:

  • Familial exudative vitreoretinopathy (FEV R) is an inherited autosomal dominant condition.
  • It exhibits nearly 100% penetrance and is prevalent in Asian populations.
  • Key signs include temporal avascular retina, abnormal vessels, and macular heterotopy.

Purpose:

  • To describe the clinical presentation, variability, and therapeutic strategies for FEVR.
  • To differentiate FEVR from retinopathy of prematurity.
  • To outline management approaches based on disease severity.

Summary:

  • FEVR presents with variable severity, from asymptomatic carriers to severe vision loss due to retinal detachment.
  • Unlike retinopathy of prematurity, FEVR affects full-term infants without oxygen exposure.
  • Therapeutic interventions include laser coagulation or cryocoagulation for exudates and vitrectomy for advanced detachments.

Impact:

  • Highlights the importance of early diagnosis and intervention in FEVR.
  • Provides a clinical guide for managing this sight-threatening inherited retinal disorder.
  • Emphasizes the need for tailored treatment based on the stage of FEVR.