Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Asthma-III: Symptoms and Complications01:24

Asthma-III: Symptoms and Complications

3.6K
Asthma, a common chronic respiratory condition, is classified considering the frequency and severity of symptoms alongside lung function impairment. Understanding this classification is essential for appropriate treatment and management. Here's a detailed look at the classification of asthma and its clinical features and complications:
Classification of Asthma
3.6K
Chronic Obstructive Pulmonary Disease-IV: Assessement and Diagnostic Studies01:27

Chronic Obstructive Pulmonary Disease-IV: Assessement and Diagnostic Studies

3.3K
Assessing and diagnosing Chronic Obstructive Pulmonary Disease (COPD) involves a detailed approach that includes a comprehensive review of medical history, physical examination, and a variety of diagnostic tests. This thorough evaluation is essential to ensure an accurate diagnosis and guide effective management strategies.
Medical History
3.3K
Chronic Obstructive Pulmonary Disease-III: Symptoms and Complications.01:25

Chronic Obstructive Pulmonary Disease-III: Symptoms and Complications.

4.0K
Understanding the variety of primary symptoms and systemic complications that characterize chronic obstructive pulmonary disease (COPD) is crucial for healthcare professionals.
Symptoms of COPD can be classified as primary or systemic. Primary symptoms relate to reduced airflow, while systemic or extrapulmonary symptoms relate to COPD's broader impact on the body.
Primary Symptoms of COPD:
4.0K
Pulmonary Function Tests01:25

Pulmonary Function Tests

996
Pulmonary Function Tests (PFTs)
Pulmonary Function Tests are crucial diagnostic tools for assessing respiratory function, particularly in patients with chronic respiratory disorders. They comprehensively evaluate lung volumes, ventilatory function, breathing mechanics, diffusion, and gas exchange. These tests help diagnose pulmonary diseases and play a significant role in monitoring disease progression, evaluating disability, and assessing response to therapy.
PFTs involve using a spirometer, a...
996
Asthma-II: Pathophysiology and Classification01:26

Asthma-II: Pathophysiology and Classification

4.8K
Asthma is a prevalent chronic respiratory condition marked by inflammation and hyperresponsiveness of the airways. Its pathophysiology involves complex interactions among inflammatory pathways, immune responses, and neural mechanisms.
Additionally, environmental and genetic factors play crucial roles in determining an individual's susceptibility to asthma and the severity of their condition.
Critical processes in asthma pathophysiology include:
4.8K
Pulmonary Cycle: Exhalation01:17

Pulmonary Cycle: Exhalation

4.7K
In terms of human respiration, the act of expelling air, known as exhalation (or expiration), operates on the principle of pressure gradients. During expiration, the pressure within the lungs exceeds that of the surrounding atmosphere. Under normal conditions, quiet breathing involves passive exhalation and is free of muscular contractions. This is because the exhalation process is driven by the natural elastic recoil of the lungs and chest wall, both of which have an inherent tendency to...
4.7K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Science, medicine and ethics during COVID-19 pandemic.

Acta paediatrica (Oslo, Norway : 1992)·2021
Same author

Return to School for Children With Tracheostomy or Requiring Noninvasive Ventilation Lessons From the First Lockdown in the United Kingdom.

Chest·2021
Same author

Proposal of 0.5 mg of protein/100 g of processed food as threshold for voluntary declaration of food allergen traces in processed food-A first step in an initiative to better inform patients and avoid fatal allergic reactions: A GA²LEN position paper.

Allergy·2021
Same author

E-Cigarettes as a Growing Threat for Children and Adolescents: Position Statement From the European Academy of Paediatrics.

Frontiers in pediatrics·2021
Same author

COVID-19 and delivery of difficult asthma services.

Archives of disease in childhood·2021
Same author

Electronic reminders and rewards to improve adherence to inhaled asthma treatment in adolescents: a non-randomised feasibility study in tertiary care.

BMJ open·2021

Related Experiment Video

Updated: Mar 20, 2026

Author Spotlight: Efficacy of Auricular Pressure Bean Therapy in Reducing Wheezing Symptoms
02:34

Author Spotlight: Efficacy of Auricular Pressure Bean Therapy in Reducing Wheezing Symptoms

Published on: May 10, 2024

2.1K

Symptom-pattern phenotype and pulmonary function in preschool wheezers.

Samatha Sonnappa1, Cristina M Bastardo, Angela Wade

  • 1Portex Unit, Respiratory Medicine and Physiology, UCL Institute of Child Health, London, United Kingdom.

The Journal of Allergy and Clinical Immunology
|June 29, 2010
PubMed
Summary

Children with multiple-trigger wheeze show abnormal lung function, unlike those with episodic wheeze. Conductive airways ventilation inhomogeneity (S(cond)) is the most sensitive measure for detecting these pulmonary function abnormalities in young children.

More Related Videos

Simplified Whole Body Plethysmography to Characterize Lung Function During Respiratory Melioidosis
07:27

Simplified Whole Body Plethysmography to Characterize Lung Function During Respiratory Melioidosis

Published on: February 24, 2023

4.0K
Employing the Forced Oscillation Technique for the Assessment of Respiratory Mechanics in Adults
06:11

Employing the Forced Oscillation Technique for the Assessment of Respiratory Mechanics in Adults

Published on: February 9, 2022

6.5K

Related Experiment Videos

Last Updated: Mar 20, 2026

Author Spotlight: Efficacy of Auricular Pressure Bean Therapy in Reducing Wheezing Symptoms
02:34

Author Spotlight: Efficacy of Auricular Pressure Bean Therapy in Reducing Wheezing Symptoms

Published on: May 10, 2024

2.1K
Simplified Whole Body Plethysmography to Characterize Lung Function During Respiratory Melioidosis
07:27

Simplified Whole Body Plethysmography to Characterize Lung Function During Respiratory Melioidosis

Published on: February 24, 2023

4.0K
Employing the Forced Oscillation Technique for the Assessment of Respiratory Mechanics in Adults
06:11

Employing the Forced Oscillation Technique for the Assessment of Respiratory Mechanics in Adults

Published on: February 9, 2022

6.5K

Area of Science:

  • Pediatric Pulmonology
  • Respiratory Medicine
  • Allergy and Immunology

Background:

  • Preschool wheezing phenotypes are typically categorized by onset, duration, and atopic status.
  • Previous research has not focused on symptom-pattern phenotypes like episodic (viral) and multiple-trigger wheeze.
  • Understanding these distinct wheeze patterns is crucial for accurate diagnosis and management.

Purpose of the Study:

  • To determine if multiple-trigger wheezers exhibit more pulmonary function abnormalities and higher fraction of exhaled nitric oxide (FeNO) than episodic (viral) wheezers.
  • To compare the sensitivity of multiple-breath wash-out techniques versus specific airways resistance (sR(aw)) in detecting lung function deficits in preschool wheezers.
  • To investigate the impact of atopy and current wheeze status on these measures.

Main Methods:

  • Pulmonary function tests including FeNO, multiple-breath wash-out (lung clearance index [LCI], conductive airways ventilation inhomogeneity [S(cond)]), and sR(aw) were performed on healthy children and those with recurrent wheeze (ages 4-6).
  • Participants were sub-grouped based on symptom pattern (multiple-trigger vs. episodic [viral]), atopic status, and current wheeze symptoms.
  • Statistical analyses compared measures between groups and assessed the sensitivity of different pulmonary function tests.

Main Results:

  • Multiple-trigger wheezers showed significantly increased LCI (11%), S(cond) (211%), and sR(aw) (15%) compared to episodic (viral) wheezers.
  • Episodic (viral) wheezers' pulmonary function did not differ significantly from healthy controls.
  • Higher FeNO was observed in those with current atopy or wheeze, but this did not significantly impact pulmonary function.
  • Abnormalities were detected in LCI (39%), S(cond) (68%), and sR(aw) (26%) among multiple-trigger wheezers.

Conclusions:

  • Multiple-trigger wheeze is linked to pulmonary function abnormalities, irrespective of atopic status or current wheeze.
  • Conductive airways ventilation inhomogeneity (S(cond)) emerged as the most sensitive indicator of abnormal pulmonary function in preschool wheezers.
  • These findings highlight the distinct physiological impact of different wheeze phenotypes in young children.