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Updated: Jun 11, 2026

Design and Implementation of an fMRI Study Examining Thought Suppression in Young Women with, and At-risk, for Depression

Design and Implementation of an fMRI Study Examining Thought Suppression in Young Women with, and At-risk, for Depression

Published on: May 19, 2015

Upper alpha activity during working memory processing reflects abnormal inhibition in major depression.

R A Segrave¹, R H Thomson, N R Cooper

¹Monash Alfred Psychiatry Research Centre, The Alfred and Monash University School of Psychology and Psychiatry, Victoria, Australia. R.Segrave@alfred.org.au

Journal of Affective Disorders

|June 29, 2010

Summary

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Major depressive disorder (MDD) patients show increased alpha activity during working memory (WM) tasks, suggesting enhanced neural inhibition as a compensatory mechanism for cognitive processing.

Area of Science:

Neuroscience
Cognitive Psychology
Psychiatry

Background:

Resting-state EEG in major depressive disorder (MDD) reveals alpha band abnormalities.
The functional relevance of these alpha abnormalities to depressive psychopathology is unclear.
Alpha activity modulation during cognitive tasks may clarify its role in MDD.

Purpose of the Study:

Examine differences in alpha modulation during working memory (WM) processing in MDD.
Investigate if alpha activity patterns in MDD align with impaired inhibitory processes.

Main Methods:

Used event-related synchronization (ERS) in the upper alpha band.
Examined a modified Sternberg WM task during the retention interval.
Included 15 acutely depressed and 15 never-depressed female participants.

Related Experiment Videos

Last Updated: Jun 11, 2026

Design and Implementation of an fMRI Study Examining Thought Suppression in Young Women with, and At-risk, for Depression

Design and Implementation of an fMRI Study Examining Thought Suppression in Young Women with, and At-risk, for Depression

Published on: May 19, 2015

Main Results:

MDD participants exhibited greater upper alpha ERS than controls.
This difference was observed during the information maintenance phase of WM.
The effect was localized to the left parieto-occipital cortex.

Conclusions:

Findings suggest increased inhibition of irrelevant information during WM in MDD.
This may represent a neurobiological compensation strategy.
MDD may necessitate greater neural resources for accurate cognitive performance.