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(99m)Tc-labeled-1-thio-beta-d-glucose as a new tool to temporomandibular joint inflammatory disorders diagnosis
Cláudia Borges Brasileiro1, Cinthia Mara da Fonseca Pacheco, Celso Martins Queiroz-Junior
1Departamento de Engenharia Nuclear--PCA, Escola de Engenharia, Universidade Federal de Minas Gerais (UFMG)--Avenida Presidente Antônio Carlos, 6627, CEP: 31270-100 Belo Horizonte, MG, Brazil. cbbrasileiro@gmail.com
Aim:
The aim of this study was to evaluate early detection of temporomandibular joint (TMJ) inflammatory changes based on 1-thio-beta-d-glucose radiolabeled with technetium-99m.
Method:
The method applied a TMJ inflammation model in rats followed by radiopharmaceutical synthesis, intravenous administration of (99m)Tc-1-TG and kinetic scintigraphy imaging.
Results:
Results show a significant difference of (99m)Tc-1-TG uptake between inflamed TMJ and the control joint. The biodistribution of (99m)Tc-1-TG by images showed the kidneys' excretion.
Conclusion:
As conclusion, (99m)Tc-1-TG is a helpful tool in TMJ inflammatory process detection.
