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Updated: Jun 11, 2026

A Large Animal Model for Acute Kidney Injury by Temporary Bilateral Renal Artery Occlusion
Published on: February 2, 2021
Renal blood flow redistribution during acute kidney injury
Filippo Mangione1, Valeria Calcaterra, Ciro Esposito
1Department of Internal Medicine, Section of Nephrology, University of Pavia, Pavia, Italy. filippo.mangione@unipv.it
Abstract:
We describe a case of acute kidney injury with decreased kidney perfusion in which contrast-enhanced computed tomography of the abdomen was performed for a nonrenal indication. This imaging procedure showed intrarenal blood flow redistribution from the cortex to the medulla that reversed after recovery of kidney function. Renal blood flow redistribution was described first almost a century ago in experimental models of renal ischemia, but clinical imaging studies are scarce. We provide a clear example of this phenomenon using contrast-enhanced computed tomography.
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