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Acral myxoinflammatory fibroblastic sarcoma.

H Chahdi1, A Damiri, M Oukabli

  • 1Anatomopathology Department, Mohamed V Military Teaching Hospital, Rabat, Morocco. h_chahdi@hotmail.com

Orthopaedics & Traumatology, Surgery & Research : OTSR
|June 29, 2010
PubMed
Summary

Acral myxoinflammatory fibroblastic sarcoma, a rare soft tissue tumor, typically affects extremities. This case highlights a successful surgical removal of this low-grade malignancy from a patient's finger.

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Area of Science:

  • Oncology
  • Pathology
  • Dermatology

Background:

  • Acral myxoinflammatory fibroblastic sarcoma (AMFTS) is a rare, low-grade malignant soft tissue tumor.
  • It predominantly affects the extremities of middle-aged individuals.

Observation:

  • A case report details an AMFTS in the third finger of the left hand of a middle-aged man.
  • The tumor exhibited a nodular architecture with diverse cellular areas, myxoid background, and fibrosis.
  • Neoplastic cells included spindled, epithelioid, and bizarre giant cells, resembling ganglion cells.

Findings:

  • Immunohistochemical analysis revealed strong vimentin reactivity.
  • Tumor cells showed variable positivity for CD68 and CD34.

Implications:

  • Complete surgical excision was achieved without the need for further adjuvant therapy.
  • This case contributes to understanding the clinical and pathological presentation of acral myxoinflammatory fibroblastic sarcoma.