Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Inflammation01:38

Inflammation

Overview
Inflammatory Response01:28

Inflammatory Response

An inflammatory response is a localized, nonspecific immune reaction that occurs when a tissue is injured. It is characterized by redness, swelling, heat, and pain, which are commonly called the cardinal signs and symptoms of inflammation. Inflammation can sometimes result in a loss of function.
Inflammation can be triggered by various stimuli, such as impact, abrasion, chemical irritation, infections, and extreme hot or cold temperatures. These can damage cells and connective tissue fibers,...
Chronic Inflammation: Introduction01:12

Chronic Inflammation: Introduction

Chronic inflammation is a prolonged, dysregulated immune response that persists for weeks to years when the inciting stimulus is difficult to eradicate or when self‑antigens drive ongoing reactivity. Morphologically, it is defined by mononuclear cell infiltration, progressive tissue destruction, and concurrent attempts at healing via angiogenesis and fibrosis. Compared with acute inflammation, edema is less prominent while cellular infiltration predominates; triggers include persistent...
Acute Inflammation I: Inflammatory Response01:26

Acute Inflammation I: Inflammatory Response

Acute inflammation is a rapid, short-lived physiological response to tissue injury or infection, designed to eliminate harmful agents and initiate repair. This tightly regulated process typically lasts from minutes to several days and is triggered by factors such as microbial invasion, physical trauma, or chemical injury.Recognition and Mediator ReleaseThe inflammatory response begins when resident immune cells—such as mast cells, macrophages, and dendritic cells—detect damage-associated...
Overview of Regeneration and Repair01:19

Overview of Regeneration and Repair

Regeneration and repair processes are critical in healing damages caused by injury, disease, and aging. In regeneration, the damaged tissue is entirely replaced with new growth that restores the original architecture and function. In contrast, tissue repair usually results in a fixed tissue architecture involving scar formation. Scars generally do not reestablish tissue function and may also exhibit structural abnormalities at the injury site.
Regeneration
All animals have varying degrees of...
Inflammatory Response I: Vascular and Cellular01:30

Inflammatory Response I: Vascular and Cellular

The inflammatory response is the body's defense against infection, injury, or irritation from bacteria, trauma, toxins, or heat. Inflammation helps locate and destroy pathogens and remove damaged tissue elements to heal the body. During this initial phase, fluid, blood products, and nutrients migrate to the injured area, resulting in redness, heat, swelling, ache, and loss of function. Moreover, signs of systemic inflammation include fever, increased WBC count, malaise, anorexia, nausea,...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Chitosan coating effects on biological response to niobia-modified yttria-stabilized zirconia.

The journal of advanced prosthodontics·2026
Same author

Evaluation of the remineralisation potential of a novel peptide GA-C16G2 on artificial root dentine lesions.

Journal of the mechanical behavior of biomedical materials·2026
Same author

Could Trained Immunity Impact Periapical Healing? A Biological Perspective.

International endodontic journal·2026
Same author

Reimagining Dental Education: Integrating Digital Technologies for a Global, Digitally Native Generation-A Perspective.

European journal of dentistry·2026
Same author

In Vitro and In Vivo Evaluation of Yttria-Niobia-Stabilized Zirconia Sandblasted Surface at Bone-Implant Interface with 3-Dimensional Visualization via Advanced Hard Tissue Clearing.

Biomaterials research·2026
Same author

Demineralization of Camel Dentin for Dental Tissue Engineering.

International dental journal·2026

Related Experiment Video

Updated: Jun 11, 2026

Development of a Direct Pulp-capping Model for the Evaluation of Pulpal Wound Healing and Reparative Dentin Formation in Mice
07:07

Development of a Direct Pulp-capping Model for the Evaluation of Pulpal Wound Healing and Reparative Dentin Formation in Mice

Published on: January 12, 2017

Inflammation-regeneration interplay in the dentine-pulp complex.

Paul R Cooper1, Yusuke Takahashi, Lee W Graham

  • 1Oral Biology, School of Dentistry, University of Birmingham, St Chad's Queensway, Birmingham B4 6NN, UK. p.r.cooper@bham.ac.uk

Journal of Dentistry
|June 29, 2010
PubMed
Summary
This summary is machine-generated.

Dental inflammation and regeneration are interconnected, not antagonistic. Low-grade inflammation can promote healing, while immune responses modulate dental tissue repair and defense mechanisms.

More Related Videos

Establishment of a Murine Pulp Exposure Model with a Novel Mouth-Gag for Pulpitis Research
05:16

Establishment of a Murine Pulp Exposure Model with a Novel Mouth-Gag for Pulpitis Research

Published on: October 27, 2023

Related Experiment Videos

Last Updated: Jun 11, 2026

Development of a Direct Pulp-capping Model for the Evaluation of Pulpal Wound Healing and Reparative Dentin Formation in Mice
07:07

Development of a Direct Pulp-capping Model for the Evaluation of Pulpal Wound Healing and Reparative Dentin Formation in Mice

Published on: January 12, 2017

Establishment of a Murine Pulp Exposure Model with a Novel Mouth-Gag for Pulpitis Research
05:16

Establishment of a Murine Pulp Exposure Model with a Novel Mouth-Gag for Pulpitis Research

Published on: October 27, 2023

Area of Science:

  • Dental tissue biology
  • Immunology
  • Regenerative medicine

Background:

  • Dental diseases like caries involve immune responses impacting natural tissue regeneration.
  • Understanding the interplay between defense and regeneration is crucial for broader tissue applications.

Purpose of the Study:

  • To review literature on the interaction between dental tissue defense and regeneration.
  • To identify potential cross-talk for novel research and clinical translation.

Main Methods:

  • PubMed database literature review.
  • Extensive hand searching of reference lists from relevant articles.

Main Results:

  • Inflammatory and regenerative processes in dental tissues are often viewed as separate but are significantly interrelated.
  • While severe inflammation hinders regeneration, low-grade inflammation can promote it, including angiogenic and stem cell processes.
  • Locally derived factors modulate defense and repair within dental tissues.

Conclusions:

  • The relationship between dental inflammation and regeneration is complex, with potential for promoting healing under specific conditions.
  • Further research into this cross-talk could lead to new clinical applications for tissue repair.