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Related Experiment Video

Updated: Jun 24, 2026

Inducing Apical Periodontitis in Mice
10:26

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Published on: August 6, 2019

Could Trained Immunity Impact Periapical Healing? A Biological Perspective.

Mohammed Turky1,2, Paul R Cooper3

  • 1Department of Endodontics, Faculty of Dentistry, Minia University, Minia, Egypt.

International Endodontic Journal
|June 23, 2026
PubMed
Summary
This summary is machine-generated.

Trained immunity, a form of innate immune memory, may explain varied healing after root canal treatment. This immune priming influences periapical tissue repair and bone regeneration, offering a new perspective beyond infection control.

Area of Science:

  • Immunology
  • Endodontics
  • Regenerative Medicine

Background:

Keywords:
apical periodontitisepigenesis genetichost‐pathogen interactionsimmunity

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  • Periapical healing after root canal treatment shows significant variability despite consistent microbial control.
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