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Ziprasidone induced tardive cervical dystonia
Ayse Kutlu1, Senem Dündar, Nur S Altun
1Kocaeli University, School of Medicine, Neurology Department, Kocaeli, Turkey. draysekutlu@yahoo.com
Psychopharmacology Bulletin
|June 29, 2010
Summary
Atypical depression treatment with ziprasidone caused involuntary neck movements. Botulinum Toxin A (BTX-A) therapy effectively reduced pain and head deviation in this case.
Area of Science:
- Neuroscience
- Pharmacology
- Clinical Medicine
Background:
- Atypical depression is a common diagnosis.
- Ziprasidone is an atypical antipsychotic used for depression.
- Drug-induced movement disorders are a potential side effect of antipsychotics.
Observation:
- A 50-year-old female patient developed involuntary neck movements after 4 months of ziprasidone treatment for atypical depression.
- The involuntary movements persisted and worsened after ziprasidone was tapered off.
- Subsequent treatment with oral clonazepam did not alleviate the symptoms.
Findings:
- Botulinum Toxin A (BTX-A) therapy was administered to the patient for the involuntary neck movements.
- Significant reduction in neck pain and improvement in head deviation were observed after the fourth BTX-A injection.
- This suggests BTX-A may be an effective treatment for drug-induced involuntary neck movements.
Implications:
- Botulinum Toxin A (BTX-A) shows promise as a therapeutic option for managing drug-induced movement disorders, specifically tardive dystonia or related conditions.
- This case highlights the importance of recognizing and managing persistent side effects of psychotropic medications.
- Further research is warranted to explore the efficacy and safety of BTX-A in treating similar movement disorders.
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