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In Vitro Chemical Mapping of G-Quadruplex DNA Structures by Bis-3-Chloropiperidines
Published on: May 12, 2023
Bis-guanylhydrazone diimidazo[1,2-a:1,2-c]pyrimidine as a novel and specific G-quadruplex binding motif
Silvia Sparapani1, Stefania Bellini, Mekala Gunaratnam
1Cancer Research UK Biomolecular Structure Group, The School of Pharmacy, University of London, London, WC1N 1AX, UK.
Chemical Communications (Cambridge, England)
|June 29, 2010
Abstract:
A bis-guanylhydrazone derivative of diimidazo[1,2-a:1,2-c]pyrimidine has unexpectedly been found to be a potent stabiliser of several quadruplex DNAs, whereas there is no significant interaction with duplex DNA. Molecular modeling suggests that the guanylhydrazone groups play an active role in quadruplex binding.
