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Updated: Jun 11, 2026

Palladium N-Heterocyclic Carbene Complexes: Synthesis from Benzimidazolium Salts and Catalytic Activity in Carbon-carbon Bond-forming Reactions
Published on: July 30, 2017
Facile benzo-ring construction via palladium-catalyzed functionalization of unactivated sp3 C-H bonds under mild
Yiqing Feng1, Yuji Wang, Bradley Landgraf
1Department of Chemistry, The Pennsylvania State University, University Park, Pensylvania 16802, USA.
Abstract:
A practical synthetic method for the annulation of benzo-rings by the intramolecular coupling of an aryl iodide and a methylene C-H bond is described. The palladium-catalyzed C-H functionalization is directed by an aminoquinoline carboxamide group, which can be easily installed and removed. High yields and broad substrate scope were achieved. An additive of ortho-phenyl benzoic acid, identified from a systematic screening, functions as a critical ligand for the catalytic process under mild condition, even at near room temperature.
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