Vasculogenic erectile dysfunction and metabolic syndrome
Orhan Koca1, Selahattin Calışkan, Metin İ Oztürk
1Department of Urology, Haydarpasa Numune Training and Research Hospital, Istanbul, Turkey. drorhankoca@hotmail.com
The Journal of Sexual Medicine
|June 30, 2010
Summary
Erectile dysfunction (ED) is common in older men and linked to systemic diseases. Penile Doppler ultrasonography can help evaluate vascular issues in patients with metabolic syndrome (MS).
Area of Science:
- Urology
- Andrology
- Vascular Medicine
Background:
- Erectile dysfunction (ED) affects over half of men aged 40-70.
- ED is characterized by the inability to achieve or maintain an erection sufficient for intercourse.
Purpose of the Study:
- To identify factors influencing penile vascular blood flow in ED patients.
- To assess the predictability of vascular flow in men with ED.
Main Methods:
- 163 male patients with ED completed the International Index of Erectile Function (IIEF) questionnaire.
- Blood tests measured cholesterol, triglycerides, and fasting blood glucose (FBG); Body Mass Index (BMI) was calculated.
- Penile color Doppler ultrasonography (PDU) evaluated penile blood flow patterns.
Main Results:
- No significant correlation was found between arterial insufficiency and metabolic syndrome (MS).
- A significant correlation was observed between veno-occlusive dysfunction and MS.
- Penile vascular pathologies were assessed in relation to hypertension, obesity, FBG, and cholesterol.
Conclusions:
- ED prevalence rises with age and systemic diseases.
- Standard evaluations may be insufficient for comprehensive ED assessment.
- Penile Doppler ultrasonography is recommended for evaluating penile vascular structures in ED patients with MS.
More Related Videos
08:22Combined Intravital Microscopy and Contrast-enhanced Ultrasonography of the Mouse Hindlimb to Study Insulin-induced Vasodilation and Muscle Perfusion
Published on: March 20, 2017
10:31An Experimental Model of Diet-Induced Metabolic Syndrome in Rabbit: Methodological Considerations, Development, and Assessment
Published on: April 20, 2018
Related Concept Videos
01:20Disorders of the Male Reproductive System
Men's health issues are increasingly recognized as significant, with several conditions posing common threats. Among these, testicular cancer is especially prevalent in younger men, particularly those aged 20 to 35 years. The disease often manifests as a painless mass in the testicles, sometimes accompanied by a sensation of heaviness or a dull ache.
Prostate disorders are another major concern. These conditions can impair urinary flow due to the prostate's location around the urethra. Symptoms...
Prostate disorders are another major concern. These conditions can impair urinary flow due to the prostate's location around the urethra. Symptoms...
01:30Coronary Artery Disease I: Introduction
Coronary Artery Disease (CAD): An Overview with Scientific InsightsCoronary Artery Disease (CAD), often referred to as C-A-D, is a prevalent blood vessel disorder classified under the broader category of atherosclerosis. Atherosclerosis is a pathological process characterized by the hardening and narrowing of arteries due to the accumulation of atherosclerotic plaques. These plaques are composed of cholesterol, fatty substances, inflammatory cells, calcium, and fibrin, reducing blood flow to...
01:26Coronary Artery Disease II: Pathophysiology
Coronary Artery Disease (CAD) originates from a series of events that impair the function of coronary arteries, the blood vessels responsible for delivering oxygen-rich blood to the heart muscle. The pathophysiology of CAD is closely linked to atherosclerosis, a chronic inflammatory and lipid-driven condition affecting the vascular endothelium.1. Endothelial DamageThe process begins with damage to the vascular endothelium, which serves as a protective barrier between the blood and the vessel...
01:29Hypertension II: Pathophysiology
Hypertension is a chronic condition in which the blood's force against artery walls is excessively high, posing risks such as heart disease. The condition's underlying mechanisms involve complex interactions among the cardiovascular, kidney, and autonomic nervous systems.Renin-Angiotensin-Aldosterone System (RAAS): This system significantly influences blood pressure regulation. When blood pressure decreases, the kidneys secrete renin. This enzyme transforms angiotensinogen, a plasma protein,...
01:28Treatment for Pulmonary Arterial Hypertension: Phosphodiesterase Inhibitors
Phosphodiesterase 5 (PDE5) inhibitors are potent enzymes that function to hydrolyze cyclic nucleotides to their corresponding 5' monophosphates. Their unique biochemical properties have been applied in treating Pulmonary Arterial Hypertension (PAH).
Among the PDE5 inhibitors, sildenafil (Revatio) stands out as a competitive and selective inhibitor. It operates by elevating cellular levels of cGMP and augmenting signaling through the cGMP-PKG pathway, promoting vasodilation. Upon oral...
Among the PDE5 inhibitors, sildenafil (Revatio) stands out as a competitive and selective inhibitor. It operates by elevating cellular levels of cGMP and augmenting signaling through the cGMP-PKG pathway, promoting vasodilation. Upon oral...
01:24Type II Diabetes II: Pathophysiology
PathophysiologyType 2 diabetes mellitus (T2DM ) is a chronic metabolic disorder characterized by insulin resistance and progressive pancreatic β-cell dysfunction, leading to impaired glucose homeostasis. It results from interactions among genetic predisposition, environmental factors, and metabolic stressors, such as overnutrition and a sedentary lifestyle.Insulin Resistance and Glucose DysregulationEarly T2DM involves insulin resistance in skeletal muscle, adipose tissue, and the liver.