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Updated: Jun 11, 2026

Using Cholesky Decomposition to Explore Individual Differences in Longitudinal Relations between Reading Skills
Published on: September 17, 2019
Symptoms as latent variables
Dennis J McFarland1, Loretta S Malta
1Laboratory of Neural Injury and Repair, Wadsworth Center, New York State Department of Health, Albany, NY 12201, USA. mcfarlan@wadsworth.org
Abstract:
In the target article, Cramer et al. suggest that diagnostic classification is improved by modeling the relationship between manifest variables (i.e., symptoms) rather than modeling unobservable latent variables (i.e., diagnostic categories such as Generalized Anxiety Disorder). This commentary discusses whether symptoms represent manifest or latent variables and the implications of this distinction for diagnosis and treatment.
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