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Related Experiment Videos

Prorenin secretion from human placenta perfused in vitro.

T Lenz1, G D James, J H Laragh

  • 1Cardiovascular Center, New York Hospital, Cornell University Medical College, New York 10021.

The American Journal of Physiology
|June 1, 1991
PubMed
Summary

The human placenta primarily secretes prorenin into the maternal circulation, not the fetal circulation. Little active renin is found in maternal or fetal blood, suggesting limited placental prorenin activation.

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Area of Science:

  • Reproductive biology
  • Endocrinology
  • Renal physiology

Background:

  • The human placenta produces hormones like human chorionic gonadotropin (hCG), progesterone, and estradiol.
  • The role of placental renin and prorenin in maternal and fetal circulation is not fully understood.

Purpose of the Study:

  • To investigate placental secretion of renin (prorenin plus renin) into maternal and fetal circulations.
  • To compare placental renin secretion rates with those of hCG, progesterone, and estradiol.
  • To determine the transfer and activation of prorenin between maternal and fetal circulations.

Main Methods:

  • Measurement of hormones and renin in maternal and fetal circulations.
  • Ex vivo perfusion of maternal and fetal placental circuits with recombinant human prorenin.

Related Experiment Videos

  • Analysis of prorenin to renin conversion in different circulations.

    • Main Results:

    • Estradiol and progesterone transferred to both circulations.
    • Renin (predominantly prorenin) and hCG were mainly secreted into the maternal circulation.
    • Prorenin did not transfer from maternal to fetal circulation; minimal transfer occurred from fetal to maternal circulation.
    • No prorenin activation was observed in maternal or fetal circulations, though some activation occurred in tissue extracts.

    Conclusions:

    • The human placenta likely secretes prorenin into the maternal circulation.
    • Limited transfer and no activation of prorenin occur between maternal and fetal circulations.
    • The placenta may secrete a small amount of active renin into the maternal circulation.