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Human parechovirus infections in monkeys with diarrhea, China

T L Shan1, C M Wang, L Cui

  • 1Shanghai Jiao Tong University, Shanghai, 200240, People's Republic of China.

Emerging Infectious Diseases
|July 1, 2010
PubMed

Insights

Human parechovirus (HPeV) was detected in monkeys with diarrhea. These findings suggest that monkeys could be reservoirs for HPeV and valuable models for studying this infection.

Area of Science:

  • Veterinary Virology
  • Zoonotic Diseases
  • Primate Health

Background:

  • Limited data exists on human parechovirus (HPeV) infections in animal populations.
  • Understanding animal reservoirs is crucial for controlling zoonotic disease transmission.

Purpose of the Study:

  • To investigate the presence of HPeV in animals, specifically non-human primates.
  • To characterize a novel HPeV isolate from a symptomatic monkey.

Main Methods:

  • Fecal samples from diarrheal monkeys were analyzed using 5' untranslated region reverse transcription-polymerase chain reaction (RT-PCR).
  • The complete genome of a detected HPeV isolate was sequenced.

Main Results:

  • Human parechovirus (HPeV) was successfully detected in the feces of monkeys exhibiting diarrhea.
  • The complete genome of one HPeV isolate, designated SH6, was sequenced and characterized.

Conclusions:

  • Monkeys may act as potential reservoirs for human parechovirus (HPeV), facilitating zoonotic transmission.
  • Non-human primates can serve as relevant animal models for investigating HPeV pathogenesis and disease mechanisms.

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