Local hyperthermia enhances thrombosis in aneurysms containing platinum coils

Area of Science:

• Biomedical Engineering
• Interventional Neuroradiology
• Materials Science

Background:

• Incomplete packing of cerebral aneurysms with platinum coils can lead to rupture or regrowth.
• Platinum coils generate heat when exposed to alternating magnetic fields (AMF).

Purpose of the Study:

• To investigate the use of AMF-induced hyperthermia to promote thrombogenesis in incompletely packed aneurysms.
• To assess the safety and efficacy of this technique in a canine model.

Main Methods:

• Experiments were conducted using glass models and canine carotid artery aneurysms.
• Platinum coil weight, fluid flow rates, and temperature elevation were analyzed.
• Activated coagulation time (ACT) of canine blood was measured at various temperatures.
• Angiographic changes were monitored after AMF application in canine models.

Main Results:

• Platinum weight correlated positively with temperature elevation; flow rate showed a negative logarithmic correlation.
• Elevated blood temperatures shortened ACT.
• AMF application successfully elevated intra-aneurysmal temperatures in canine models.
• Hyperthermia promoted angiographically evident thrombogenesis in remnant aneurysm spaces.

Conclusions:

• Local hyperthermia induced by AMF can effectively complete aneurysm obliteration after coil embolization.
• This method shows promise for treating ruptured aneurysms and preventing early rerupture.