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A Murine Model of Carotid Aneurysm Formation

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Takayasu arteritis with multiple intracranial aneurysms. A case report.

H A Sonwalkar¹, A K Gupta, S Purkayastha

¹Department of Radiology, Sree Chithra Institute of Medical Science and Technology, Trivandrum, India - hemantsonwalkar@hotmail.com.

Interventional Neuroradiology : Journal of Peritherapeutic Neuroradiology, Surgical Procedures and Related Neurosciences

|July 1, 2010

Summary

This report details a rare case of multiple cerebral aneurysms linked to Takayasu aortitis, the first documented in India. The study suggests abnormal cerebral hemodynamics, not direct arteritis, may cause these aneurysms.

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Area of Science:

Neurology
Cardiology
Vascular Surgery

Background:

Takayasu aortitis is a rare, chronic inflammatory disease affecting the aorta and its branches.
Cerebral aneurysms are abnormal bulges in the blood vessels of the brain.
The association between Takayasu aortitis and cerebral aneurysms is exceptionally rare, with few cases reported globally.

Purpose of the Study:

To report a rare case of multiple cerebral aneurysms in a patient with Takayasu aortitis.
To highlight the first reported instance of this association in India.
To investigate the potential etiological factors contributing to aneurysm formation in this context.

Main Methods:

Case report of a 50-year-old female patient presenting with subarachnoid hemorrhage.
Diagnostic imaging including CT scan, cerebral angiography, and aortography.
Review of existing literature on Takayasu aortitis and cerebral aneurysms.

Main Results:

The patient exhibited features of Takayasu arteritis Type III with occlusion of major cerebral arteries and saccular aneurysms.
Subarachnoid hemorrhage and subsequent cerebral infarction were observed.
Surgical intervention for aneurysms was performed, but the patient had a fatal outcome.

Conclusions:

This case represents the eighth reported instance of cerebral aneurysms associated with Takayasu aortitis worldwide and the first from India.
Abnormal cerebral hemodynamics secondary to arterial involvement by Takayasu aortitis is proposed as the primary mechanism for aneurysm development.
Further research is warranted to elucidate the pathophysiology and optimize management strategies for this rare condition.