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Updated: Feb 9, 2026

Mouse Kidney Transplantation: Models of Allograft Rejection
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Mouse Kidney Transplantation: Models of Allograft Rejection

Published on: October 11, 2014

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A complementary approach to treating antibody-mediated transplant rejection

Peter S Heeger1

  • 1Renal Division, Mount Sinai School of Medicine, New York, New York 10029, USA. peter.heeger@mssm.edu

Kidney International
|July 1, 2010
PubMed

Current treatment for antibody-mediated kidney transplant rejection is inadequate. Tillou and colleagues administered recombinant C1 inhibitor to block complement activation to prevent antibody-initiated injury in sensitized baboon recipients of kidney allografts. These early but encouraging results support further testing of the safety and efficacy of complement inhibition as part of a comprehensive strategy to treat this disease, both in animal models and ultimately in humans.

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