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Updated: Jun 11, 2026

Biomolecular Imaging of Cellular Uptake of Nanoparticles using Multimodal Nonlinear Optical Microscopy
Published on: May 16, 2022
Digital phase conjugation of second harmonic radiation emitted by nanoparticles in turbid media
Chia-Lung Hsieh1, Ye Pu, Rachel Grange
1School of Engineering, EPFL, Station 17, 1015 Lausanne, Switzerland. chia-lung.hsieh@epfl.ch
Abstract:
We demonstrate focusing coherent light on a nanoparticle through turbid media based on digital optical phase conjugation of second harmonic generation (SHG) field from the nanoparticle. A SHG active nanoparticle inside a turbid medium was excited at the fundamental frequency and emitted SHG field as a point source. The SHG emission was scattered by the turbid medium, and the scattered field was recorded by off-axis digital holography. A phase-conjugated beam was then generated by using a phase-only spatial light modulator and sent back through the turbid medium, which formed a nearly ideal focus on the nanoparticle.
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