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Zebrafish Model of Neuroblastoma Metastasis
Published on: March 14, 2021
Refractory dilated cardiomyopathy associated with metastatic neuroblastoma
Peter Carlson1, John L Jefferies, Debra Kearney
1Baylor College of Medicine, Houston, Texas, USA.
Abstract:
A 2-year-old African American male presented with heart failure and an abdominal mass. Computerized tomography (CT) scan revealed a 7 cm adrenal lesion, confirmed as poorly differentiated neuroblastoma (NB). CT and meta-iodobenzoguanidine (MIBG) scans identified multiple metastases, but cardiac MIBG imaging was absent. Cardiac ejection fraction (EF) was 8% with 7% shortening fraction. The patient underwent six cycles of chemotherapy and investigational immunotherapy. Cardiac function improved to 26% EF. However, the tumor proved unresponsive to treatment. The patient died from stage IV congestive heart failure (CHF) and progressive NB. Autopsy confirmed dilated cardiomyopathy with endocardial fibroelastosis.
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