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Updated: Jun 11, 2026

Unraveling Entropic Rate Acceleration Induced by Solvent Dynamics in Membrane Enzymes
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Unraveling Entropic Rate Acceleration Induced by Solvent Dynamics in Membrane Enzymes

Published on: January 16, 2016

Domain motion and interdomain hot spots in a multidomain enzyme

Gwo-Yu Chuang1, Ritcha Mehra-Chaudhary, Chi-Ho Ngan

  • 1Department of Biomedical Engineering, Boston University, Boston, Massachusetts 02215, USA.

Protein Science : a Publication of the Protein Society
|July 1, 2010
PubMed
Summary

Computational solvent mapping reveals subtle conformational changes in Pseudomonas aeruginosa phosphomannomutase/phosphoglucomutase (PMM/PGM). This method is more sensitive than traditional structure superposition for detecting ligand-induced shifts in enzyme active sites and interdomain regions.

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