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Updated: Jun 11, 2026
09:29
Isolation of Intermediate Filament Proteins from Multiple Mouse Tissues to Study Aging-associated Post-translational Modifications
Published on: May 18, 2017
Plasma membrane microdomains in aging and disease.
Yoshiko Ohno-Iwashita1, Yukiko Shimada, Masami Hayashi
1Tokyo Metropolitan Institute of Gerontology, Itabashi-ku, Tokyo, Japan. yiwast@iwakimu.ac.jp
Geriatrics & Gerontology International
|July 2, 2010
Summary
Lipid rafts, specialized plasma membrane domains, are crucial for cellular signaling. Their dysfunction is linked to aging, cellular senescence, and age-related diseases.
Area of Science:
- Cell Biology
- Molecular Biology
- Biochemistry
Background:
- The plasma membrane is vital for cellular functions, including signal transduction.
- Membrane microdomains, known as lipid rafts, act as signaling platforms.
- Lipid rafts are enriched in cholesterol and sphingolipids, concentrating signaling molecules.
Purpose of the Study:
- To investigate the role of lipid rafts in cellular signaling.
- To explore the connection between lipid rafts and age-associated cellular dysregulation.
- To understand the implication of lipid rafts in senile and lifestyle-related diseases.
Main Methods:
- Analysis of plasma membrane composition and structure.
- Investigating signaling pathways within lipid rafts.
- Comparative studies on lipid raft function in aging cells versus young cells.
Main Results:
- Lipid rafts are implicated in T-cell receptor signaling and cellular senescence.
- Dysregulation of lipid rafts is associated with age-related decline in cellular signaling.
- Lipid rafts play a role in the pathogenesis of senile and lifestyle-related diseases.
Conclusions:
- Lipid rafts are critical regulators of cellular signaling pathways.
- Alterations in lipid raft structure and function contribute to aging and age-related diseases.
- Targeting lipid rafts may offer therapeutic strategies for age-related conditions.
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