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Vasculogenesis and Angiogenesis: Molecular and Cellular Controls. Part 2: Interactions between Cell and Extracellular

N Kubis¹, B I Levy

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Summary

Angiogenesis, the formation of new blood vessels, relies on growth factors and extracellular matrix remodeling. This review updates knowledge on the roles of coagulation, fibrinolysis, metalloproteinases, and adhesion molecules in this vital process.

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Last Updated: Jun 11, 2026

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Published on: November 2, 2016

Area of Science:

Biomedical science
Cell biology
Vascular biology

Background:

Angiogenesis is crucial for development and disease.
Endothelial cell migration and proliferation are key steps.
Extracellular matrix remodeling is essential for angiogenesis.

Purpose of the Study:

To review the role of the coagulation and fibrinolysis system in angiogenesis.
To update data on metalloproteinases' function in blood vessel formation.
To explore the involvement of adhesion molecules in angiogenesis.

Main Methods:

Literature review of scientific publications.
Analysis of data on molecular mechanisms.
Synthesis of information on key regulatory systems.

Main Results:

Angiogenesis is initiated by growth factors and receptors.
Extracellular proteolysis facilitates endothelial cell movement.
Coagulation, fibrinolysis, metalloproteinases, and adhesion molecules are integral to angiogenesis.

Conclusions:

The coagulation and fibrinolysis system significantly impacts angiogenesis.
Metalloproteinases are critical for extracellular matrix degradation during angiogenesis.
Adhesion molecules mediate endothelial cell interactions essential for new blood vessel formation.