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Updated: Jun 11, 2026

Closure of a Patent Foramen Ovale (PFO): An Intervention Sequence
Published on: December 23, 2022
Patent foramen ovale and stroke
Shunichi Homma1, Marco R Di Tullio
1Division of Cardiology, Columbia University, College of Physicians & Surgeons, 630 West 168th Street, New York, NY 10032, USA. sh23@columbia.edu
A patent foramen ovale (PFO) is linked to a higher risk of cryptogenic stroke. This review covers the evidence, detection methods, and prevention strategies for recurrent stroke in PFO patients.
Area of Science:
- Cardiology
- Neurology
- Vascular Medicine
Background:
- Patent foramen ovale (PFO) is a common cardiac anomaly.
- PFO has been implicated as a potential cause of cryptogenic stroke.
Purpose of the Study:
- To review the association between PFO and cryptogenic stroke.
- To discuss technical aspects of PFO detection.
- To outline preventive strategies for recurrent cerebral events.
Main Methods:
- Literature review of studies investigating PFO and stroke.
- Analysis of diagnostic techniques for PFO identification.
- Evaluation of therapeutic interventions for stroke prevention in PFO patients.
Main Results:
- Evidence suggests a correlation between PFO and increased risk of ischemic stroke.
- Various imaging modalities aid in PFO detection.
- Preventive measures aim to reduce the risk of secondary stroke.
Conclusions:
- PFO is a significant risk factor for cryptogenic stroke.
- Accurate PFO detection is crucial for risk stratification.
- Management strategies focus on preventing recurrent cerebrovascular events.
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