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Heterogeneous Removal of Water-Soluble Ruthenium Olefin Metathesis Catalyst from Aqueous Media Via Host-Guest Interaction
Published on: August 23, 2018
Chemoselective olefin metathesis transformations mediated by ruthenium complexes.
Steven P Nolan1, Hervé Clavier
1School of Chemistry, University of St Andrews, St Andrews, UK KY16 9ST. snolan@st-andrews.ac.uk
Chemical Society Reviews
|July 2, 2010
Summary
Ruthenium catalysts enable diverse metathesis reactions. This review highlights how catalyst structure influences stereochemistry and product distribution in metathesis, focusing on chemoselectivity, a rarely studied aspect.
Area of Science:
- Organic Chemistry
- Catalysis
- Stereochemistry
Background:
- Ruthenium-catalyzed metathesis reactions are extensively studied.
- Development of diverse ruthenium catalysts has been significant.
- Focus has primarily been on catalytic performance, with limited research on chemoselectivity.
Purpose of the Study:
- To review the stereochemistry of new C=C bonds formed via ruthenium-mediated metathesis.
- To analyze chemoselectivity as a function of catalyst structure.
- To discuss macrocyclization and ligand effects on metathesis products.
Main Methods:
- Critical review of existing literature on ruthenium-mediated metathesis.
- Analysis of stereochemical outcomes in ring-closing and cross-metathesis.
- Examination of product distributions in macrocyclization and tandem processes.
Main Results:
- Catalyst structure significantly impacts the stereochemistry of newly formed C=C bonds.
- Ligand choice (phosphine vs. N-heterocyclic carbene) influences product distribution.
- Disparities in macrocyclization can lead to dimeric or monomeric products.
Conclusions:
- Chemoselectivity in ruthenium-catalyzed metathesis is highly dependent on catalyst and ligand design.
- Understanding stereochemical control is crucial for optimizing metathesis reactions.
- Further research into chemoselectivity can unlock new synthetic pathways.
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