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Progressive myoclonic epilepsies: review of clinical, molecular and therapeutic aspects
Luis Felipe Mendonça de Siqueira1
1Federal University of Minas Gerais, Belo Horizonte, Brazil. luismensiq@hotmail.com
Abstract:
The progressive myoclonic epilepsies (PME) are a rare group of inherited neurodegenerative diseases with debilitating evolution, resistance to treatment and poor prognosis. However, advances in molecular genetics have enabled better understanding of the pathogenesis of these diseases, bringing hope for improved treatment options in the future. This manuscript is an overview of the clinical and molecular findings in patients with PME. Furthermore, it describes therapeutic approaches that are currently recommended in the literature.
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