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Conscious and Non-conscious Representations of Emotional Faces in Asperger's Syndrome

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Right hemisphere dysfunction and emotional processing in ALS: an fMRI study.

A Palmieri¹, M Naccarato, S Abrahams

¹Department of Neurosciences, University of Padova, via Giustiniani 5, 35128, Padova, Italy. arianna.palmieri@unipd.it

Journal of Neurology

|July 2, 2010

Summary

This summary is machine-generated.

Amyotrophic lateral sclerosis (ALS) patients show abnormal emotional processing. Brain imaging reveals atypical left-hemisphere activation and reduced right-hemisphere activity during emotional tasks, suggesting extra-motor neurodegeneration.

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Area of Science:

Neuroscience
Neurology
Cognitive Psychology

Background:

Emotional processing alterations are observed in amyotrophic lateral sclerosis (ALS).
The functional neuroanatomical basis of emotional processing deficits in ALS remains unclear.

Purpose of the Study:

To investigate the functional anatomical correlates of processing aversive information in ALS patients.
To compare brain activation patterns between ALS patients and healthy controls during emotional tasks.

Main Methods:

Functional magnetic resonance imaging (fMRI) was used to examine brain activity.
Nine non-demented ALS patients and 10 healthy controls performed emotional attribution and memory recognition tasks involving unpleasant and neutral stimuli.

Main Results:

Healthy controls exhibited greater right middle frontal gyrus activation for unpleasant vs. neutral words and right-sided activation during emotional recognition.
ALS patients demonstrated increased left-hemisphere and reduced right-hemisphere activation in both emotional tasks.
These patterns suggest extra-motor neurodegeneration affecting emotional circuits, potentially overlapping with frontotemporal dementia (FTD).

Conclusions:

ALS is associated with atypical brain activation patterns during emotional processing.
Findings indicate extra-motor neurodegeneration impacting emotional regulation circuits in ALS.
The observed neurodegeneration may involve pathways common to frontotemporal dementia.