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An early T cell lineage commitment checkpoint dependent on the transcription factor Bcl11b

Long Li1, Mark Leid, Ellen V Rothenberg

  • 1Division of Biology 156-29, California Institute of Technology, Pasadena, CA 91125, USA.

Science (New York, N.Y.)
|July 3, 2010
PubMed
Summary

The zinc finger transcription factor Bcl11b is crucial for T lymphocyte lineage commitment. This transcription factor is essential for suppressing natural killer cell potential and silencing stem cell genes during T cell development.

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