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Published on: February 3, 2026
Chemoradiotherapy in pancreatic carcinoma
Sushmita Pathy1, Subhash Chander
1Department of Radiation Oncology, All India Institute Of Medical Sciences, Ansari Nagar, New Delhi - 110 029, India.
Summary
Pancreatic cancer is often diagnosed late, limiting surgery. Adjuvant chemoradiotherapy offers improved survival for advanced cases, while new agents require further study.
Area of Science:
- Oncology
- Surgical Oncology
- Radiation Oncology
Background:
- Pancreatic cancer diagnosis frequently occurs at advanced stages, diminishing the effectiveness of surgical resection.
- Loco-regional failure and distant metastasis are common post-operative challenges in pancreatic cancer management.
Purpose of the Study:
- To evaluate the efficacy of adjuvant therapies, including radiotherapy and chemotherapy, in improving loco-regional control for pancreatic cancer.
- To review the current evidence on chemoradiotherapy for advanced unresectable pancreatic carcinoma and explore novel therapeutic agents.
Main Methods:
- Review of existing studies on adjuvant therapy for pancreatic cancer.
- Analysis of data regarding intra-operative radiotherapy and its survival benefits.
- Assessment of chemoradiotherapy outcomes in advanced pancreatic cancer patients.
Main Results:
- Surgical resection has limited value due to late presentation of pancreatic cancer.
- Adjuvant radiotherapy and chemotherapy improve loco-regional control.
- Intra-operative radiotherapy shows controversial survival benefits.
- Chemoradiotherapy demonstrates improved survival in advanced unresectable pancreatic carcinoma.
Conclusions:
- Adjuvant chemoradiotherapy is a valuable treatment option for advanced pancreatic cancer, enhancing survival.
- Further clinical investigation is warranted for novel agents like topoisomerase I inhibitors in pancreatic cancer treatment.
