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DNAzyme 10-23 - Based Nanomachines for Nucleic Acid Recognition
Published on: February 9, 2024
An ultrahighly sensitive and selective electrochemical DNA sensor via nicking endonuclease assisted current change
Jinghua Chen1, Jing Zhang, Juan Li
1Ministry of Education Key Laboratory of Analysis and Detection for Food Safety, Department of Chemistry, Fuzhou University, Fuzhou, Fujian 350002, China.
Chemical Communications (Cambridge, England)
|July 3, 2010
Abstract:
Based on the "nicking endonuclease assisted" detection strategy, a novel electrochemical biosensor for the sequence-specific detection of DNA with ultrahigh sensitivity and selectivity is developed. By employing the above strategy, this DNA biosensor can detect as low as 0.068 fM target DNA and exhibits high discrimination ability even against a single-base mismatch.
