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[Mastocytosis as the cause of childrens' abdominal discomforts]

Marja-Leena Lähdeaho1, Marja-Leena Tuomi, Martine Vornanen

  • 1Tampereen yliopisto, lääketieteen laitos ja TAYS:n lastenklinikka, PL 2000, 33521 Tampere.

Duodecim; Laaketieteellinen Aikakauskirja
|July 6, 2010
PubMed

Insights

Mastocytosis, a condition with increased mast cells, can cause severe gastrointestinal issues in children. Prompt treatment with histamine receptor blockers effectively healed ulcers and normalized growth.

Area of Science:

  • Pediatric Hematology
  • Gastroenterology
  • Dermatology

Context:

  • Mastocytosis involves an abnormal increase in mast cells.
  • Urticaria pigmentosa is the most common presentation.
  • Gastrointestinal manifestations can be severe in pediatric cases.

Purpose:

  • To report on four pediatric cases of mastocytosis with significant gastrointestinal symptoms.
  • To highlight the efficacy of histamine receptor blockers in managing these symptoms.

Summary:

  • Two of the four children experienced upper gastrointestinal ulcerations.
  • Other common symptoms included vomiting, heartburn, abdominal pain, and crying spells.
  • Symptoms are attributed to mediators like histamine released from mast cells.

Impact:

  • Histamine receptor blockers are crucial for treating mastocytosis-related symptoms.
  • Adequate medication led to ulcer healing, symptom relief, and normalized growth in the reported cases.

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