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Updated: Jun 11, 2026

Testing Targeted Therapies in Cancer using Structural DNA Alteration Analysis and Patient-Derived Xenografts
Published on: July 25, 2020
Testing for CHEK2 in the cancer genetics clinic: ready for prime time?
1Womens College Research Institute, 790 Bay, Toronto, Ontario, Canada. Steven.narod@wchospital.ca
Abstract:
The 1100delC mutation of the CHEK2 gene was found to be a cause of breast cancer in 2002. The lifetime risk of breast cancer among women with a mutation and with a family history of breast cancer is approximately 25%. These women are good candidates for screening with MRI and for chemoprevention with tamoxifen. It is reasonable to test for this single mutation when women undergo testing for BRCA1 and BRCA2.
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