Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Peptic Ulcer01:27

Peptic Ulcer

Peptic ulcers are erosive lesions of the gastric or duodenal lining, most commonly caused by Helicobacter pylori infection. This Gram-negative, helical bacterium has adapted to survive the stomach’s acidic environment by producing urease, which converts urea into ammonia and carbon dioxide. The ammonia neutralizes gastric acid in the bacterium’s immediate environment, allowing colonization of the gastric mucosa. H. pylori attaches to mucus-secreting epithelial cells, penetrates the mucus...
Peptic Ulcer Disease I: Introduction01:25

Peptic Ulcer Disease I: Introduction

Peptic ulcer disease (PUD) involves breaks in the gastrointestinal tract's mucosal lining, primarily in the stomach and duodenum, with less frequent occurrences in the lower esophagus or near the pylorus.Ulcers can be acute or chronic. Acute ulcers are short-lived with minimal inflammation and heal quickly after the irritant is removed. Chronic ulcers persist, may recur, and often cause scarring due to ongoing tissue damage. Superficial erosions affect only the mucosal layer and are called...
Peptic Ulcer Disease I: Introduction01:30

Peptic Ulcer Disease I: Introduction

Peptic Ulcer Disease (PUD) is characterized by mucosal excavation in the esophagus, stomach, pylorus, or duodenum. It can manifest as acute or chronic based on the extent and duration of mucosal involvement.
An acute ulcer, marked by superficial erosion and minimal inflammation, swiftly resolves upon identifying and addressing the underlying cause. In contrast, a chronic ulcer persists, potentially eroding through the muscular wall and forming fibrous tissue.
Peptic ulcers can also be...
Peptic Ulcer Disease II: Pathophysiology01:24

Peptic Ulcer Disease II: Pathophysiology

Peptic ulcer disease develops when protective mechanisms of the gastrointestinal mucosa are overwhelmed by harmful factors, leading to localized erosions in the stomach or proximal duodenum. The main causes are Helicobacter pylori infection and chronic use of nonsteroidal anti-inflammatory drugs (NSAIDs).Helicobacter pylori–Induced InjuryBacterial Adaptation and Colonization:H. pylori is a spiral, Gram-negative bacterium adapted to the acidic stomach. and transmitted through oral-oral or...
Peptic Ulcer Disease II: Pathophysiology01:28

Peptic Ulcer Disease II: Pathophysiology

Peptic Ulcer Disease (PUD) is characterized by the development of ulcers in the stomach or duodenal mucosa. Its pathophysiology is complex, involving a balance between damaging and protective elements.
Damaging agents such as Helicobacter pylori, gastric acid, pepsin, and nonsteroidal anti-inflammatory drugs (NSAIDs) can weaken the mucosal defense, allowing hydrogen ions to infiltrate back and harm epithelial cells.
Peptic Ulcer Disease III: Clinical Manifestations and Diagnostic Studies01:28

Peptic Ulcer Disease III: Clinical Manifestations and Diagnostic Studies

Peptic ulcer disease (PUD) presents with diverse symptoms depending on the location and severity of the ulcer. Clinical manifestations of peptic ulcer include dull pain and a burning sensation in the mid-epigastric region.
Few clinical manifestations differentiate gastric ulcers from duodenal ulcers. Distinctions in the location, timing, and pain relief are crucial for healthcare providers in differentiating between gastric and duodenal ulcers during clinical assessments.

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Community-Based Telehealth Approach Improves Specialist Access for Individuals with Increased Cancer Risk in Low-Resource Settings.

Cancers·2025
Same author

Telehealth Utilization in Oral Medicine and Oral and Maxillofacial Surgery.

Telemedicine journal and e-health : the official journal of the American Telemedicine Association·2023
Same author

Immune-Related Long Non-Coding RNA Signatures for Tongue Squamous Cell Carcinoma.

Current oncology (Toronto, Ont.)·2023
Same author

UBE2C promotes the progression of head and neck squamous cell carcinoma.

Biochemical and biophysical research communications·2019
Same author

Oral Cancer: Novel Concepts for the Oral Health Care Practitioner.

Journal of the California Dental Association·2016
Same author

Oral Cancer Chernoprevention: Current Status and Future Direction.

Journal of the California Dental Association·2016
Same journal

Increased Risk of Cutaneous T-Cell Lymphoma Development after Dupilumab Use for Atopic Dermatitis.

Dermatologic therapy·2024
Same journal

Correction to "Adjuvant PD-1 inhibitor versus high-dose interferon α-2b for Chinese patients with cutaneous and acral melanoma: A retrospective cohort analysis".

Dermatologic therapy·2022
Same journal

A case of erythema nodosum concomitant with ulcerative colitis relieved by tofacitinib.

Dermatologic therapy·2022
Same journal

A case report of vitiligo following toripalimab therapy for a patient with metastatic melanoma.

Dermatologic therapy·2022
Same journal

High versus low dose oral isotretinoin in the treatment of cutaneous and genital warts.

Dermatologic therapy·2022
Same journal

Evaluation of the efficacy and relapse rates of treatment protocols for moderate acne using isotretinoin based on the global acne grading system: Randomized, controlled, comparative study.

Dermatologic therapy·2022
See all related articles

Related Experiment Video

Updated: Jun 11, 2026

Examination of Oral Candida Infection in Primary Sjögren's Syndrome Patients
05:26

Examination of Oral Candida Infection in Primary Sjögren's Syndrome Patients

Published on: March 1, 2024

Aphthous ulcers.

Diana V Messadi1, Fariba Younai

  • 1UCLA School of Dentistry, Los Angeles, CA 90095, USA. dmessadi@dentistry.ucla.edu

Dermatologic Therapy
|July 6, 2010
PubMed
Summary
This summary is machine-generated.

Recurrent aphthous ulcers are common oral lesions. This guide covers their differential diagnosis and management, including topical and systemic therapies for these painful mouth sores.

More Related Videos

Th17 Inflammation Model of Oropharyngeal Candidiasis in Immunodeficient Mice
08:02

Th17 Inflammation Model of Oropharyngeal Candidiasis in Immunodeficient Mice

Published on: February 18, 2015

Gastric Point of Care Ultrasound in Adults: Image Acquisition and Interpretation
05:50

Gastric Point of Care Ultrasound in Adults: Image Acquisition and Interpretation

Published on: September 22, 2023

Related Experiment Videos

Last Updated: Jun 11, 2026

Examination of Oral Candida Infection in Primary Sjögren's Syndrome Patients
05:26

Examination of Oral Candida Infection in Primary Sjögren's Syndrome Patients

Published on: March 1, 2024

Th17 Inflammation Model of Oropharyngeal Candidiasis in Immunodeficient Mice
08:02

Th17 Inflammation Model of Oropharyngeal Candidiasis in Immunodeficient Mice

Published on: February 18, 2015

Gastric Point of Care Ultrasound in Adults: Image Acquisition and Interpretation
05:50

Gastric Point of Care Ultrasound in Adults: Image Acquisition and Interpretation

Published on: September 22, 2023

Area of Science:

  • Oral Medicine
  • Dermatology
  • Immunology

Background:

  • Aphthous ulcers are highly prevalent oral mucosal diseases globally.
  • Characterized by recurrent, painful, small to ovoid ulcerations with erythematous halos.
  • Similar oral lesions can indicate underlying systemic conditions.

Purpose of the Study:

  • To provide a comprehensive overview of the differential diagnosis for aphthous ulceration.
  • To offer a practical management guide for recurrent aphthous ulceration.
  • To discuss current topical and systemic therapeutic options.

Main Methods:

  • Literature review of aphthous ulceration diagnosis and management.
  • Clinical presentation analysis of aphthous ulcers and similar oral lesions.
  • Synthesis of therapeutic strategies for recurrent aphthous ulceration.

Main Results:

  • Differential diagnosis includes infectious, autoimmune, and neoplastic conditions.
  • Management strategies focus on symptom relief and reducing recurrence.
  • Topical corticosteroids and systemic immunomodulators are key therapeutic classes.

Conclusions:

  • Accurate diagnosis is crucial to differentiate aphthous ulcers from systemic disease manifestations.
  • Effective management involves a combination of symptomatic treatment and targeted therapy.
  • Further research into the etiology and novel treatments for aphthous ulcers is warranted.