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Updated: Jun 11, 2026
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Treatment of Liver Metastases Using an Internal Target Volume Method for Stereotactic Body Radiotherapy
Published on: May 8, 2018
[Normal tissue tolerance to external beam radiation therapy: liver].
B De Bari1, Y Pointreau, E Rio
1Département de Radiothérapie-Oncologie, Centre Hospitalier Lyon-Sud, Université Claude-Bernard Lyon 1 et EA3738, 69310 Pierre-Bénite, France. berardino.de-bari@chu-lyon.fr
Summary
This review covers radiobiological criteria for normal tissue complication probability (NTCP) in liver radiotherapy. It provides recommendations for conformal 3D radiotherapy and stereotactic liver irradiation to minimize radiation-induced liver disease (RILD).
Area of Science:
- Radiation oncology
- Hepatology
- Medical physics
Background:
- The liver's anatomical location places it near radiation targets and critical structures.
- It can be both a target for radiation therapy (e.g., liver tumors) and an organ at risk (OAR).
- Radiation-induced liver disease (RILD) is a critical dose-limiting complication.
Purpose of the Study:
- To review the radiobiological criteria underpinning normal tissue complication probability (NTCP) data for the liver.
- To provide recommendations for radiotherapy planning in liver cancer treatment.
- To guide conformal 3D radiotherapy and stereotactic liver irradiation techniques.
Main Methods:
- Literature review of radiobiological principles related to liver tolerance.
- Analysis of existing NTCP data and models for liver irradiation.
- Synthesis of recommendations for clinical practice in liver radiotherapy.
Main Results:
- Established radiobiological justification for NTCP data in liver irradiation.
- Provided specific recommendations for conformal 3D radiotherapy.
- Outlined considerations for stereotactic liver irradiation, focusing on dose constraints and RILD prevention.
Conclusions:
- Accurate radiobiological modeling is crucial for liver radiotherapy.
- Implementing recommended guidelines can optimize treatment efficacy and minimize RILD.
- Further research may refine NTCP models for diverse liver irradiation scenarios.
