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[Biological rhythms for anaesthesia and intensive care].
G Dispersyn1, D Chassard, L Pain
1Inserm U, CHRU de Strasbourg, université Louis-Pasteur, France.
Annales Francaises D'Anesthesie Et De Reanimation
|July 6, 2010
Summary
Understanding biological rhythms improves anesthetic drug use, as these rhythms affect drug effectiveness and patient responses. Anesthetics can also disrupt biological rhythms, impacting hormone secretion and patient health.
Area of Science:
- Chronopharmacology
- Anesthesiology
- Sleep Medicine
Context:
- Biological rhythms influence the time-of-day effects of anesthetic drugs.
- These rhythms modulate pharmacokinetic, toxic, and pharmacodynamic parameters of anesthetics, analgesics, and antibiotics.
Purpose:
- To explore the bidirectional relationship between biological rhythms and anesthetic drugs.
- To highlight how anesthetics affect biological rhythm regulation and vice versa.
Summary:
- Anesthetic drugs exhibit time-of-day dependent effects explained by chronopharmacology.
- General anesthetics can disrupt endogenous biological rhythms, including sleep-wake and circadian temperature cycles.
- This disruption can lead to altered circadian secretion of hormones and affect pain and cardiovascular physiology.
Impact:
- Emphasizes the clinical relevance of biological rhythms in anesthesia, pain management, and intensive care.
- Suggests considering biological rhythms in the design and interpretation of studies in these fields.
- Underscores the potential for desynchronization of biological rhythms to negatively impact patient outcomes.
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