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Published on: December 3, 2019
[Percutaneous coronary intervention in HIV infected patients with human immunodeficiency virus admitted with acute
Roberto Martín-Reyes1, Guillermo Galeote, Raúl Moreno
1Servicio de Cardiología, Hospital Universitario La Paz, Madrid, España. rmartinereyes@yahoo.es
Insights
Patients with human immunodeficiency virus (HIV) experiencing acute coronary syndrome (ACS) show similar cardiovascular mortality despite younger age and fewer traditional risk factors. Percutaneous coronary intervention (PCI) success rates were lower in HIV patients.
Area of Science:
- Cardiology
- Infectious Diseases
- Public Health
Context:
- Human immunodeficiency virus (HIV) infection is increasingly associated with cardiovascular events.
- Understanding cardiovascular risk factors and outcomes in HIV patients is crucial for clinical management.
Purpose:
- To analyze risk factors for acute coronary syndrome (ACS) onset.
- To evaluate in-hospital prognosis in HIV patients undergoing percutaneous coronary intervention (PCI).
Summary:
- HIV patients undergoing PCI for ACS were younger and had higher smoking rates but similar clinical presentations to HIV-negative patients.
- Angiography revealed less complex coronary artery disease in HIV patients, with lower PCI success rates (75% vs. 85%).
- Hospital mortality rates were comparable between HIV-positive (8.7%) and HIV-negative (1.7%) patients.
Impact:
- Despite younger age and fewer traditional risk factors, HIV patients with ACS face similar cardiovascular mortality risks.
- Findings highlight the need for comprehensive cardiovascular risk assessment and management in the HIV population.
- Lower PCI success in HIV patients warrants further investigation into underlying mechanisms and optimized treatment strategies.
Introduction:
Human immunodeficiency virus (HIV) has been linked in recent years with a higher rate of cardiovascular events. The aim of our study was to analyze the main risk factors associated with the onset of an acute coronary syndrome (ACS) and in-hospital prognosis in patients with HIV, undergoing percutaneous coronary intervention (PCI).
Patients And Methods:
We studied the baseline clinical characteristics, angiographic findings, results of PCI and in-hospital outcome in 23 patients with HIV hospitalized for an ACS between September 2006 and March 2009. The results were compared with 60 HIV-negative patients admitted with an ACS.
Results:
HIV patients showed a lower average age and a higher rate of smoking. From a clinical point of view there were no statistically significant differences in clinical presentation, with a similar incidence of ACS with or without ST segment elevation ACS. HIV patients presented a non significant higher incidence of cardiogenic shock on admission (13% HIV vs 8% HIV negative, p 0,301). HIV-negative patients angiography showed the most calcified multivessel involvement with the highest number of diseased vessels (2.35 vs. 1.45, p<0.001). PCI results: HIV patients presented a lower rate of success (TIMI 3 final); 75% versus 85% in HIV-negative patients (p=0.105). There was no significant difference in hospital mortality (8.7 vs 1.7%, p=0.129).
Conclusions:
HIV patients hospitalized for an ACS, despite being younger and presenting lower prevalence of traditional cardiovascular risk factors, did not present differences in terms of cardiovascular mortality compared with HIV negative patients.
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