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Targeted anti-cancer therapy in the elderly
Wilson Gonsalves1, Apar Kishor Ganti
1Department of Internal Medicine, Creighton University Medical Center, Omaha, NE, United States.
Targeted cancer therapies offer hope for older adults, but careful consideration of individual risks and benefits is crucial. This review examines the efficacy, cost, and toxicity of these treatments in the elderly population.
Area of Science:
- Geriatric Oncology
- Pharmacology
- Clinical Medicine
Background:
- Cancer disproportionately affects individuals over 65, making it a significant geriatric health concern.
- Preserving functional independence and quality of life are primary goals in treating elderly cancer patients.
- Targeted therapies present a potential for effective cancer treatment in older adults with reduced toxicity.
Purpose of the Study:
- To review the current literature on targeted cancer therapies in the elderly population.
- To evaluate the efficacy, cost-effectiveness, and toxicity of approved targeted agents for older cancer patients.
- To provide a balanced perspective on the use of targeted therapies in geriatric oncology.
Main Methods:
- Comprehensive literature search of approved targeted agents in cancer therapy.
- Analysis of studies focusing on efficacy, cost-effectiveness, and toxicity in patients aged 65 and older.
- Synthesis of current evidence regarding the application of targeted therapies in the elderly.
Main Results:
- The review synthesizes data on the performance of various targeted agents in elderly cancer patients.
- Evidence regarding the cost-effectiveness of these treatments in the geriatric population is examined.
- Toxicity profiles and management strategies specific to older adults are discussed.
Conclusions:
- Targeted therapies hold promise for elderly cancer patients, but require individualized risk-benefit assessment.
- Further research is needed to optimize the use of targeted agents in geriatric oncology.
- Personalized treatment approaches are essential for maximizing outcomes and quality of life in older adults with cancer.
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